Pulsed electromagnetic fields influence hyaline cartilage extracellular matrix composition without affecting molecular structure

Effects of pulsed electromagnetic fields on articular hyaline cartilage: review of experimental and clinical studies.

Osteoarthritis (OA) is the most common disorder of the musculoskeletal system and is a consequence of mechanical and biological events that destabilize tissue homeostasis in articular joints. Controlling chondrocyte death and apoptosis, function, response to anabolic and catabolic stimuli, matrix synthesis or degradation and inflammation is the most important target of potential chondroprotecti...

Molecular Adhesion between Cartilage Extracellular Matrix Macromolecules

In this study, we investigated the molecular adhesion between the major constituents of cartilage extracellular matrix, namely, the highly negatively charged proteoglycan aggrecan and the type II/IX/XI fibrillar collagen network, in simulated physiological conditions. Colloidal force spectroscopy was applied to measure the maximum adhesion force and total adhesion energy between aggrecan end-at...

Pulsed electromagnetic fields and cancer.

Influence of shielding gas composition on weld structure in pulsed Nd: YAG laser welding

This work studied the effect of additions of carbon dioxide to argon shielding gas on the weld shape and microstructure of ST14 steel in pulsed Nd: YAG laser welding. By additions of carbon dioxide up to 15%,the weld area and depth/width ratio decreases while rising of carbon dioxide up to 25% causes increasing of weld area and depth/width ratio. It is observed that the weld metal microstructur...

Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions.

This study establishes that the physical state of the extracellular matrix can regulate integrin-mediated cytoskeletal assembly and tyrosine phosphorylation to generate two distinct types of cell-matrix adhesions. In primary fibroblasts, alpha(5)beta(1) integrin associates mainly with fibronectin fibrils and forms adhesions structurally distinct from focal contacts, independent of actomyosin-me...